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A FOUR (2009-2012)YEAR AUDIT OF ORAL SQUAMOUS CELL CARCINOMA AMONG PATIENTS SEEN AT THE ORAL HISTOPATHOLOGY LABORATORY IN UNIVERSITY OF NAIROBI DENTAL HOSPITAL

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SUMMARY
Background: Oral squamous carcinoma arises from the mucosal epithelium when the squamous
cells undergo mutation and begin to proliferate at an abnormally high rate and metastasize. Oral
squamous cell carcinoma currently accounts for 85-90% of all malignancies on the oral region
making it the major cancer in this area. Few studies have been done regarding the
clinicohistopathological and socio-demographic features of osee in Kenya.

SUMMARY

Background: Oral squamous carcinoma arises from the mucosal epithelium when the squamous cells undergo mutation and begin to proliferate at an abnormally high rate and metastasize. Oral

squamous cell carcinoma currently accounts for 85-90% of all malignancies on the oral region making it the major cancer in this area. Few studies have been done regarding the

clinicohistopathological and socio-demographic features of osee in Kenya.

Objective: The objective of this study was to describe the clinicopathological features of osee among patients diagnosed with oral squamous cell carcinoma in the oral histopathology lab - UON Dental Hospital.

Study design: This was a retrospective descriptive cross-sectional study of patients' clinical records diagnosed with osee from January 2009 to December 2012.

Setting: The study was conducted at University of Nairobi Dental Hospital oral pathology lab.

Materials and methods: Data was collected from the UON DH medical records and entered into a clinical form. This data included demographic details, clinical features and

histopathological findings. Variables of interest included gender, age, primary site of the tumor, histological diagnosis. Data analysis was done using a SPSS version 16.0 and results represented in charts.

Results: A total of 181 records were included in the study. Of these, 106 (58.56%) were males and 75 (41.44%) were females. The number of males and females were almost equal in the 60-79 age group. The most commonly affected site was the tongue 52 (28.73%) followed by the buccal mucosa 21 (11.60%). Most of the lesions were ulcerated 132 (40.74%) at the time of presentation, swelling was present in 106 (32.72%), tenderness in 49 (15.12%), bleeding in 23 (7.09%) of cases and a history of smoking in 14 (4.32%) of cases. Well differentiated osee was the most common histological diagnosis at 87 (48.07%) while verrucous carcinoma had the lowest finding 5 (2.76%)

Conclusion: osee had a higher incidence in males at 106 (58.56%) than females at 75 (41.44%).

Most patients were in the 60-79 age group with 75 (41.89%) and the tongue was the most commonly site of occurrence with 52 (28.73%) cases. The most frequent symptom was ulceration at 132 (40.74%) records, at the time of presentation. Well differentiated osee was the most common histological diagnosis.

Recommendations: In order to get a representative sample, another study should be done regarding osee which includes a longer time study period ill order to sample a larger population.

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